Doberman Pinscher Dilated Cardiomyopathy
The NC State Veterinary Hospital Genetics team offers testing for genetic disorders in specific canine and feline breeds.
We have identified a second genetic mutation in Doberman pinschers with dilated cardiomyopathy (DCM) and have a new test available!
We have discovered that there are two mutations that can lead to Doberman pinscher dilated cardiomyopathy, PDK4 (NCSU DCM1) and the newly discovered NCSU DCM2. Although both PDK4 (DCM1) and DCM2 can each independently lead to the development of the disease, the risk is highest when a dog is unlucky enough to have both mutations.
We now recommend that Doberman pinschers be tested for both mutations.
Price per dog for single DCM1 or DCM2 test: $48.00
Price per dog for combo DCM1 and DCM2 test: $70.00
About Doberman pinscher DCM
Doberman pinschers are one of the most common breeds of dogs to be affected with Dilated Cardiomyopathy (DCM). When a Doberman pinscher is diagnosed with DCM, the implication of subsequent abnormalities, such as congestive heart failure and sudden death become concerns.
We have previously demonstrated that dilated cardiomyopathy is an inherited disease in the Doberman pinscher and appears to be inherited in an autosomal dominant fashion. We previously identified one genetic mutation (PDK4; NCSU DCM1) for the disease and have now identified a second, NCSU DCM2. Dogs that carry both mutations are at the highest risk of getting sick from the disease, although dogs with a mutation in either gene can develop the disease as well.
Dr. Kate Meurs of the Veterinary Cardiac Genetics Lab at North Carolina State University presents free webinars! The content is targeted to the dog owner/breeder but anyone is welcome to view the sessions.
2014 Doberman DCM Update Webinar: https://mymediasite.online.ncsu.edu/online/Play/fb1bfb27416f452d8e8174ef18300e741d
2016 Doberman DCM Update & DCM2 Gene Webinar: https://mymediasite.online.ncsu.edu/online/Play/d84281e7f40643bd84d96f0755f0cb9b1d
2019 Doberman DCM Update & DCM2 Gene